High-Throughput Sequencing Set To Enter Patient Care

High-throughput sequencing set to enter patient care.

in the Amazonian medicine ayahuasca—can produce similar results. Nor is taking a drug even necessary. Investigators seem to agree that the salutary effects come not from the compounds themselves but from the spiritual epiphany they produce, so nonpharmacologic ways of achieving the same outcome should be just as beneficial. For example, many people use meditation to attain a transcendental stat...

High-throughput sequencing technologies.

The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platfo...

SnapShot: High-Throughput Sequencing Applications

Barcoding the food chain: from Sanger to high-throughput sequencing.

Society faces the complex challenge of supporting biodiversity and ecosystem functioning, while ensuring food security by providing safe traceable food through an ever-more-complex global food chain. The increase in human mobility brings the added threat of pests, parasites, and invaders that further complicate our agro-industrial efforts. DNA barcoding technologies allow researchers to identif...

Using high-throughput barcode sequencing to efficiently map connectomes

The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision-a 'connectome'-is based on imaging methods that are slow, labor-intensive and expensive. Here, we present SYNseq, a method for converting the connectome into a form that can exploit the speed and lo...